You'll get TA_FAIL, TA_E_INVALID_HANDLE, or TA_E_PDETS if TurboActivate.dat is modified.
If you're looking to stop cracking of your app, I'll just stop you right here and let you know no company in existence can stop cracking. A handful of shadier ones lie, and say they can offer products to stop or slow down cracking. But they're frauds.
More info here: https://wyday.com/limelm/features/why/#snake-oil