Nope, that's only possible with online activation (and it doesn't require any files sent back and forth).
For re-activation of offline activation you need to go through the whole process again (except for entering the product key):
I will need to update some licenses monthly. I these licenses work offline, so each update demands few steps (the client generate a file, send a file, a receive a file, generate the response, send the response, the client validates his license).It would be great i I could them monthly, an response file with the updates. Is this possible?
Nope, that's only possible with online activation (and it doesn't require any files sent back and forth).
For re-activation of offline activation you need to go through the whole process again (except for entering the product key):