Hey Jim,
but gives no clue how far I can stray before re-activation is necessary.
After they modify every component they should re-activate. So if they change RAM -- reactivate. Switch out a harddrive -- reactivated. Etc. If they will be making a large number of changes at once -- or changes that TurboActivate considers a whole new computer, then they would be best off deactivating first, then re-activating after the changes. See: http://wyday.com/limelm/help/activations/#deactivate
Does that make sense?