I'll check into it. But I've never seen these errors before - and we haven't changed anything with shortcut creation in the last year (that's what the COM exception is complaining about). Also, I've just checked our wybuild-setup.exe and it validates as still being signed:
[attachment=0]Digital Signature Details.png[/attachment]
If you right click the setup, and it shows it's no longer signed, then something corrupted it along the way.
I've checked updating from 2.6.3.1 to 2.6.4 and it works fine for me. Also, what OS (Windows 7 x64?) are you running?